Professor at Université du Québec à Montréal, Canada
Dr. Borhane Annabi is a distinguished professor in Biochemistry at Université du Québec à Montréal (UQAM) and a leader in cancer research. With a solid academic foundation, he has significantly contributed to the fields of metabolic regulation and tumor biology. His passion for scientific inquiry is reflected in his extensive research work and commitment to mentoring emerging scientists. Dr. Annabi is known for his collaborative spirit and dedication to improving public health through innovative research. He actively engages in various scientific communities and committees, promoting ethical practices in research and enhancing institutional governance. His work has far-reaching implications in understanding metabolic disorders and cancer prevention. 🌟🔬
Professional profile
Education📚
Dr. Borhane Annabi obtained his B.Sc. in Biochemistry from Université de Montréal in 1990, laying the groundwork for a successful academic career. He pursued his M.Sc. in Biochemistry at the same institution, focusing on metabolic endocrinology, culminating in a thesis on hepatic glycogen metabolism in genetically obese Zucker rats. His dedication to research led him to earn a Ph.D. in Biochemistry in 1997, again from Université de Montréal. His doctoral research centered on the liver microsomal glucose-6-phosphatase system, exploring its transport and hydrolytic functions. This strong educational foundation, enriched by rigorous research training, has equipped Dr. Annabi with the expertise to tackle complex biological problems. His academic journey reflects his commitment to advancing the field of biochemistry and contributing to critical health-related issues. 🎓📚
Professional Experience🏛️
Dr. Annabi’s professional journey is marked by significant contributions to biochemistry and cancer research. Since 2010, he has served as a Full Professor at UQAM, where he leads research efforts in metabolic and molecular oncology. He previously held the role of Associate Professor at the Université de Montréal in the Pharmacology and Physiology Department. His administrative experience includes directing the Institutional Research Chair in Cancer Prevention and Treatment at UQAM and previously leading the Canada Research Chair in Molecular and Metabolic Oncology. Dr. Annabi has also been involved in various internal committees, enhancing research governance and ethical standards within the institution. His experience encompasses a blend of teaching, research leadership, and community service, emphasizing his commitment to academia and the scientific community. His roles reflect a dedication to fostering research excellence and mentoring the next generation of scientists. 💼🔍
Research Interest🌐
Dr. Annabi’s research interests lie primarily in metabolic regulation, cancer biology, and the molecular mechanisms underlying tumor development and progression. His work focuses on understanding how metabolic pathways influence cancer cell behavior, particularly in relation to tumor angiogenesis and growth. He is deeply engaged in studying the molecular genetics of Glycogen Storage Disease and its implications for metabolic disorders. Additionally, Dr. Annabi explores the role of membrane proteins in cellular signaling and their potential as therapeutic targets in cancer treatment. His interdisciplinary approach integrates biochemistry, genetics, and oncology, fostering innovative solutions for pressing health challenges. Dr. Annabi actively collaborates with various research institutions, promoting knowledge exchange and driving impactful research initiatives. His commitment to advancing the understanding of metabolic and cancer-related processes continues to shape the future of biochemistry and health sciences. 🔬🧬
Awards and Honors🏆
Dr. Borhane Annabi’s research excellence has garnered several accolades throughout his career. His contributions to biochemistry and cancer research have been recognized through various awards and honors, reflecting his impact on the scientific community. Notably, he has received funding from prestigious institutions, enabling significant advancements in cancer prevention and treatment research. As a founding member of key research initiatives, Dr. Annabi has played a pivotal role in shaping research directions in oncology. His involvement in professional organizations and advisory roles demonstrates recognition by peers in his field. Furthermore, his dedication to ethical research practices and mentoring young scientists has earned him respect and admiration within the academic community. These honors serve as a testament to his influence and commitment to advancing knowledge in biochemistry and health sciences. 🏆🎖️
Publications top noted📜
- Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation
🧬 B. Annabi, Y.T. Lee, S. Turcotte, E. Naud, R.R. Desrosiers, M. Champagne, … (2003)
📄 Stem Cells, 21(3), 337-347 — Citations: 427
- Mesenchymal stromal cell–derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction
🩸 M. Rafei, J. Hsieh, S. Fortier, M.Y. Li, S. Yuan, E. Birman, K. Forner, M.N. Boivin, … (2008)
📄 Blood, 112(13), 4991-4998 — Citations: 294
- Green tea polyphenol (−)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells
🍵 B. Annabi, M.P. Lachambre, N. Bousquet-Gagnon, M. Pagé, D. Gingras, … (2002)
📄 Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1542(1-3), 209-220 — Citations: 222
- Green tea catechins as novel antitumor and antiangiogenic compounds
🍃 M. Demeule, J. Michaud-Levesque, B. Annabi, D. Gingras, D. Boivin, S. Lamy, … (2002)
📄 Current Medicinal Chemistry-Anti-Cancer Agents, 2(4), 441-463 — Citations: 211
- The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression
🌱 A. Belkaid, J.C. Currie, J. Desgagnés, B. Annabi (2006)
📄 Cancer Cell International, 6, 1-12 — Citations: 201
- Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains
🔬 B. Annabi, M.P. Lachambre, N. Bousquet-Gagnon, M. Pagé, … (2001)
📄 Biochemical Journal, 353(3), 547-553 — Citations: 195
- Transmembrane topology of glucose-6-phosphatase
🔄 C.J. Pan, K.J. Lei, B. Annabi, W. Hemrika, J.Y. Chou (1998)
📄 Journal of Biological Chemistry, 273(11), 6144-6148 — Citations: 192
- Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion
💊 B. Annabi, M.P. Lachambre, K. Plouffe, R. Moumdjian, R. Béliveau (2009)
📄 Pharmacological Research, 60(5), 438-445 — Citations: 190
- Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms
🔍 B. Annabi, D. Shédid, P. Ghosn, R.L. Kenigsberg, R.R. Desrosiers, … (2002)
📄 Journal of Vascular Surgery, 35(3), 539-546 — Citations: 188
- Activation of the extracellular signal-regulated protein kinase (ERK) cascade by membrane-type-1 matrix metalloproteinase (MT1-MMP)
⚙️ D. Gingras, N. Bousquet-Gagnon, S. Langlois, M.P. Lachambre, B. Annabi, … (2001)
📄 FEBS Letters, 507(2), 231-236 — Citations: 154
- The gene for glycogen-storage disease type 1b maps to chromosome 11q23
🧬 B. Annabi, B.C. Mansfield, H. Hiraiwa, K.J. Lei, T. Ubagai, … (1998)
📄 The American Journal of Human Genetics, 62(2), 400-405 — Citations: 148
- Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors
🌿 B. Annabi, E. Naud, Y.T. Lee, N. Eliopoulos, J. Galipeau (2004)
📄 Journal of Cellular Biochemistry, 91(6), 1146-1158 — Citations: 122
- ANG4043, a novel brain-penetrant peptide–mAb conjugate, is efficacious against HER2-positive intracranial tumors in mice
💥 A. Regina, M. Demeule, S. Tripathy, S. Lord-Dufour, J.C. Currie, M. Iddir, … (2015)
📄 Molecular Cancer Therapeutics, 14(1), 129-140 — Citations: 120
- Caveolin and cavin family members: dual roles in cancer
⚖️ R. Gupta, C. Toufaily, B. Annabi (2014)
📄 Biochimie, 107, 188-202 — Citations: 111
