Assistant research fellow at Clinical Research Center at the Affiliated Hospital of Guizhou Medical University, China
Prof. Dingāan Zhou is an esteemed researcher and associated research fellow at the Clinical Research Center of the Affiliated Hospital of Guizhou Medical University. He is also a postgraduate mentor at the School of Clinical Laboratory Science, Guizhou Medical University. š„š
Professional profile
Educationš
Prof. Zhou earned his PhD in Biochemistry and Molecular Biology from Fudan University in Shanghai, China, in December 2012. His doctoral research focused on the causative genes and mechanisms of genetic diseases such as dyschromatosis universalis hereditarian (DUH) and autosomal dominant congenital cataract. šš¬
Professional Experiencešļø
Following his PhD, Prof. Zhou worked as an Assistant Research Fellow at the First Affiliated Hospital of Chongqing Medical University starting in March 2013. His work there delved into the mechanisms underlying DUH phenotypes and the role of SASH1 as a tumor suppressor in breast cancer. In March 2017, he returned to Guiyang, his hometown, to join the Affiliated Hospital of Guizhou Medical University. š„š
Research Interestš
Prof. Zhou’s research interests are broad and include the identification of causative genes and mechanisms in rare genetic diseases, such as DUH, multiple endocrine neoplasia type 1 (MEN1), Retinitis Pigmentosa, 11 Ī²-hydroxylase deficiency (11Ī²-OHD), and Schmid type metaphyseal chondrodysplasia (SMCD). He is also focused on the post-translational modifications (phosphorylation and ubiquitylation) of key molecules in breast cancer. š§¬š¬
Awards and Honorsš
Prof. Zhou has been honored with the Thousand Talents Innovation Award under the Hundred Million Talent Introduction Plan of Guizhou Province. This prestigious award recognizes his significant contributions and innovations in his field. šš
Achievementsš
- PhD in Biochemistry and Molecular Biology: Awarded by Fudan University, focusing on genetic diseases such as dyschromatosis universalis hereditarian (DUH) and congenital cataract. šš¬
- Research on DUH and Breast Cancer: Investigated mechanisms of DUH phenotypes and the role of SASH1 as a tumor suppressor in breast cancer during his tenure at the First Affiliated Hospital of Chongqing Medical University. šš§¬
- Thousand Talents Innovation Award: Received the prestigious award under the Hundred Million Talent Introduction Plan of Guizhou Province, recognizing his impactful research and contributions. šš
- Broad Research Scope: Conducted extensive research on genetic diseases, including MEN1, Retinitis Pigmentosa, 11 Ī²-hydroxylase deficiency (11Ī²-OHD), and Schmid type metaphyseal chondrodysplasia (SMCD). š§¬š
- Post-Translational Modification Studies: Explored phosphorylation and ubiquitylation modifications of key molecules in breast cancer, contributing valuable insights to cancer research. š§¬š¬
Publications top notedš
- “A novel genomic rearrangement on chr19q13.42 leads to PRPF31-associated retinitis pigmentosa”
Authors: Lu, Q., Yang, J., Xiong, Y., Zhang, M., Zhou, D.
Journal: Clinical and Experimental Ophthalmology, 2024, 52(5), pp. 595ā598
Citations: 1 šš¬
- “Blockade of a novel MAP4K4-LATS2-SASH1-YAP1 cascade inhibits tumorigenesis and metastasis in luminal breast cancer”
Authors: Yang, P., Li, Y., Hou, J., Zeng, X., Zhou, D.
Journal: Journal of Biological Chemistry, 2024, 300(6), 107309
Citations: 0 šš«
- “The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-Ī²1/Smads/Snail1 axis”
Authors: Li, Y., Zhou, Y., Zhao, C., Zhou, D., Jin, F.
Journal: Oral Oncology, 2024, 152, 106798
Citations: 2 šš
- “Dickkopf-1 is an immune infiltration-related prognostic biomarker of head and neck squamous cell carcinoma”
Authors: Zhao, C., Liu, L., He, Q., Zhou, D., Jin, F.
Journal: Aging, 2024, 16(4), pp. 3837ā3855
Citations: 1 šš¬
- “Unequal crossing over between CYP11B2 and CYP11B1 causes 11 Ī² -hydroxylase deficiency in a consanguineous family”
Authors: Xiong, Y., Zeng, Z., Liang, T., Zhang, M., Zhou, D.
Journal: Journal of Steroid Biochemistry and Molecular Biology, 2023, 233, 106375
Citations: 5 šš
- “Retyping and molecular pathology diagnosis of dyschromatosis universalis hereditaria”
Authors: Zhou, D., Yang, P., Chen, H.
Journal: Experimental Dermatology, 2023, 32(9), pp. 1334ā1343
Citations: 1 šš¬
- “The PER3 rs772027021 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria”
Authors: Chen, H., Yang, P., Yang, D., Xing, Q., Zhou, D.
Journal: Journal of Molecular Medicine, 2023, 101(3), pp. 279ā294
Citations: 3 šš¬
- “The biological clock gene BMAL1 inhibits the proliferation, migration and invasion of radiation-resistant nasopharyngeal carcinoma cell line 5-8FR by regulating PI3K/Akt/MMP-2/9 signaling pathway”
Authors: Li, Y., Zhao, C., Liu, L., Zhou, J., Jin, F.
Journal: Chinese Journal of Radiation Oncology, 2022, 31(11), pp. 1039ā1045
Citations: 0 šš«
- “Association between platelets and in-hospital mortality in critically ill patients with tumours: a retrospective cohort study”
Authors: Zhao, C., Qin, Z., Tang, Y., Zhou, D., Jin, F.
Journal: BMJ Open, 2022, 12(4), e053691
Citations: 1 šš¬
