Guo-Hai Zhang is an Associate Professor at the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University. His research primarily focuses on targeted therapy and drug resistance mechanisms in lung cancer. He has made significant contributions to understanding the role of wild-type EGFR and p53 in non-small cell lung cancer (NSCLC), as well as the molecular basis of p53 mitochondrial localization. Guo-Hai Zhang has conducted numerous research projects funded by the National Natural Science Foundation of China (NSFC) and Guangxi NSFC, resulting in 20 SCI papers published in reputable journals.
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Scopus Profile
Guo-Hai Zhang has authored or co-authored 20 SCI papers published in journals such as J Med Chem, J Biol Chem, Biochem Pharmacol, and Eur J Med Chem. These publications demonstrate his impact and recognition in the field of lung cancer research, particularly in understanding targeted therapy and drug resistance mechanisms.
Citations: 566 citations by 514 documents
Documents: 27
h-index: 14
Education
Guo-Hai Zhang pursued his Ph.D. in the medical field at Nanjing University. Prior to that, he obtained a Master’s degree from Huaqiao University and a Bachelor’s degree from Shandong University of Science and Technology, both focusing on molecular medicine and chemistry.
Research Focus
Guo-Hai Zhang’s research primarily focuses on targeted therapy and drug resistance mechanisms in lung cancer, particularly non-small cell lung cancer (NSCLC). His work includes elucidating the role of wild-type EGFR and p53 in NSCLC, understanding the molecular mechanisms underlying drug resistance, and exploring intervention methods to overcome resistance.
Professional Journey
Guo-Hai Zhang’s professional journey began as a Research Associate at the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, where he conducted research from 2011 to 2017. Since December 2017, he has held the position of Associate Professor at the same institution, continuing his research in targeted therapy and drug resistance mechanisms in lung cancer.
Honors & Awards
Guo-Hai Zhang’s contributions to the field of lung cancer research have earned him recognition and honors, although specific awards and honors are not mentioned in the provided information.
Publications Noted & Contributions
Guo-Hai Zhang has made notable contributions to the field of lung cancer research through his publications. Some of his key contributions include elucidating the role of wild-type EGFR and p53 in NSCLC, understanding the molecular mechanisms of drug resistance, and exploring intervention methods to overcome resistance. His research findings have been published in reputable journals such as J Med Chem, J Biol Chem, Biochem Pharmacol, and Eur J Med Chem.
Title: Small-molecule MX-C2/3 suppresses non-small cell lung cancer progression via p53 activation
Authors: Li, L., Du, W., Wang, H., …, Zeng, S., Zhang, G.
Journal: Chemico-Biological Interactions, 2022, 366, 110142
Citations: 1
Title: Therapeutic restoring p53 function with small molecule for oncogene-driven non-small cell lung cancer by targeting serine 392 phosphorylation
Authors: Li, L., Li, P., Ma, X., …, Peng, Y., Zhang, G.
Journal: Biochemical Pharmacology, 2022, 203, 115188
Citations: 3
Title: Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment
Authors: Zhang, D., Zhao, Y., Wang, L., …, He, S., Li, E.
Journal: American Journal of Respiratory Cell and Molecular Biology, 2022, 67(2), pp. 227–240
Citations: 1
Title: Targeting entry into mitochondria for increased anticancer efficacy of BCL-XL-selective inhibitors in lung cancer
Authors: Li, L., Li, P., Song, H., …, Peng, Y., Zhang, G.
Journal: Pharmacological Research, 2022, 177, 106095
Citations: 2
Title: Glycyrrhizic acid inhibits SARS-CoV-2 infection by blocking spike protein-mediated cell attachment
Authors: Li, J., Xu, D., Wang, L., …, Li, E., He, S.
Journal: Molecules, 2021, 26(20), 6090
Citations: 32
Research Timeline
Guo-Hai Zhang’s research timeline spans from his tenure as a Research Associate from 2011 to 2017 to his current position as an Associate Professor, which he has held since December 2017. Throughout this time, he has been actively involved in conducting research projects funded by the National Natural Science Foundation of China (NSFC) and Guangxi NSFC.
Collaborations and Projects
Guo-Hai Zhang has collaborated on various research projects focused on targeted therapy and drug resistance mechanisms in lung cancer. His research group has conducted projects funded by the National Natural Science Foundation of China (NSFC) and Guangxi NSFC, contributing to the understanding of lung cancer biology and the development of targeted therapies.
