Prof. Raj Ramesar | Medicine and Dentistry | Best Researcher Award
Director: Research Unit at The University of Cape Town, South Africa
Prof. Raj Ramesar is a distinguished geneticist and researcher specializing in human genetics, genomics, and precision medicine. As Head of the Division of Human Genetics and Director of the MRC Genomics and Precision Medicine Research Unit at the University of Cape Town (UCT), he has made pioneering contributions to understanding the genetic basis of hereditary cancers, particularly familial colorectal cancer. His work has led to advancements in genetic testing, risk assessment, and clinical management, earning international recognition, including the Human Genome Organisation (HUGO) Africa Award and the UCT Vice-Chancellor’s Alan Pifer Award for Research Excellence. Prof. Ramesar has played a key role in developing genomic research infrastructure in Africa, collaborating on global initiatives, supervising numerous PhD theses, and advancing precision medicine applications. His research extends to inherited retinal disorders, contributing to clinical trials for genetic blindness treatments. His leadership continues to shape genomic medicine for public health benefits in Africa and beyond.
Professional Profile
Education
Prof. Raj Ramesar obtained his academic and professional training in human genetics, laying a strong foundation for his contributions to medical genomics. He earned his Ph.D. in Human Genetics from the University of Cape Town (UCT), where he later became a leading academic and researcher. His postgraduate studies focused on the genetic basis of hereditary cancers and inherited disorders, which positioned him at the forefront of genomic medicine in Africa. Over the years, he has engaged in numerous advanced training programs and international collaborations, enhancing his expertise in precision medicine, genomic research, and bioinformatics. As an educator, he has mentored numerous postgraduate students and played a pivotal role in developing genetic research infrastructure in South Africa. His commitment to education extends beyond the university, as he actively participates in initiatives that promote genetic literacy and capacity-building in Africa. His academic journey reflects a deep commitment to advancing genetic research and education globally.
Professional Experience
Prof. Raj Ramesar is a distinguished geneticist with a career spanning several decades, primarily at the University of Cape Town (UCT). He serves as the Head of the Division of Human Genetics and the Department of Pathology at UCT and its affiliated hospitals.
Prof. Ramesar is also the Director of the South African Medical Research Council’s (SAMRC) Genomic and Precision Medicine Research Unit, where he leads research on the genetic underpinnings of inherited cancers and retinal degenerative disorders.
His work has been instrumental in identifying novel genes and mutations within South African populations, with a recent focus on genetic studies in indigenous African communities. Beyond his research, he contributes to the scientific community by serving on editorial boards of international journals and holding leadership roles, including chairing the board of the Africa Genome Education Institute.
Prof. Ramesar’s professional journey reflects a steadfast commitment to advancing human genetics and improving health outcomes through precision medicine.
Research Interest
Prof. Raj Ramesar’s research interests primarily focus on human genetics, with a strong emphasis on hereditary cancers, inherited disorders, and genomic medicine. His work explores the genetic basis of diseases such as colorectal cancer and retinal dystrophies, aiming to develop early detection strategies and targeted therapies. He is deeply involved in precision medicine, leveraging genomic data to tailor healthcare solutions for diverse populations, particularly in Africa. His research also extends to bioinformatics, gene-environment interactions, and ethical considerations in genetic research. As a leader in African genomics, he is dedicated to addressing health disparities through genetic studies, fostering translational research that bridges the gap between laboratory discoveries and clinical applications. Additionally, he actively contributes to capacity-building initiatives, training researchers and clinicians in genomic methodologies. His work has significant implications for personalized medicine, public health policy, and the integration of genetic research into mainstream healthcare systems.
Award and Honor
Prof. Raj Ramesar, Head of the Division of Human Genetics at the University of Cape Town (UCT), has been honored with several prestigious awards recognizing his significant contributions to human genetics. In 2009, he received the UCT Vice-Chancellor’s Alan Pifer Award for his impactful research.
In 2015, he was elected to the UCT College of Fellows, acknowledging his exceptional academic achievements.
The following year, Prof. Ramesar was awarded the inaugural Africa Award by the Human Genome Organisation (HUGO) in recognition of his outstanding contributions to human genetics on the continent.
More recently, he was nominated for the NSTF-South32 Lifetime Award, further highlighting his enduring impact in the field.
Research Skill
Prof. Raj Ramesar possesses extensive research skills in human genetics, genomic medicine, and molecular biology. His expertise lies in identifying genetic markers associated with inherited diseases, particularly in the African population. He has mastered advanced genomic sequencing techniques, bioinformatics analysis, and molecular diagnostics to uncover genetic predispositions to conditions such as inherited cancers and retinal degenerative disorders. His research involves interdisciplinary collaboration, integrating clinical data with genetic insights to develop precision medicine approaches. Prof. Ramesar is highly skilled in genetic epidemiology, population genetics, and translational research, ensuring that scientific discoveries have practical healthcare applications. His ability to lead large-scale genomic studies, mentor young researchers, and contribute to global genetic research initiatives underscores his scientific acumen. He has also played a pivotal role in establishing genetic research frameworks in South Africa, promoting ethical research practices, and advancing the field of genomic medicine in Africa and beyond.
Conclusion
Dr. Rajkumar Ramesar is highly suitable for the Best Researcher Award. His outstanding contributions to human genetics, leadership in genomic research, and commitment to capacity-building in Africa make him a strong candidate. With his international recognition, innovative research, and dedication to precision medicine, he exemplifies the qualities of an award-winning researcher.
Publications Top Noted
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Distinct Dysregulated Pathways in Sporadic and Lynch Syndrome‐Associated Colorectal Cancer Offer Insights for Targeted Treatment
- Authors: May J. Krause, Musalula Sinkala, Raj Ramesar
- Year: 2025
- Citation: Krause MJ, Sinkala M, Ramesar R. Distinct Dysregulated Pathways in Sporadic and Lynch Syndrome‐Associated Colorectal Cancer Offer Insights for Targeted Treatment. FEBS Lett. 2025; DOI: 10.1002/1873-3468.70010.
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Screening of Inherited Retinal Disease Patients in a Low‐Resource Setting Using an Augmented Next‐Generation Sequencing Panel
- Authors: Nicole Midgley, George Rebello, Lara K. Holtes, Raj Ramesar, Lisa Roberts
- Year: 2024
- Citation: Midgley N, Rebello G, Holtes LK, Ramesar R, Roberts L. Screening of Inherited Retinal Disease Patients in a Low‐Resource Setting Using an Augmented Next‐Generation Sequencing Panel. Mol Genet Genomic Med. 2024; DOI: 10.1002/mgg3.70046.
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Genomic Medicine in the Developing World: Cancer Spectrum, Cumulative Risk and Survival Outcomes for Lynch Syndrome Variant Heterozygotes with Germline Pathogenic Variants in the MLH1 and MSH2 Genes
- Authors: Lutricia Ndou, Ramadhani Chambuso, Ursula Algar, Adam Boutall, Paul Goldberg, Raj Ramesar
- Year: 2024
- Citation: Ndou L, Chambuso R, Algar U, Boutall A, Goldberg P, Ramesar R. Genomic Medicine in the Developing World: Cancer Spectrum, Cumulative Risk and Survival Outcomes for Lynch Syndrome Variant Heterozygotes with Germline Pathogenic Variants in the MLH1 and MSH2 Genes. Biomedicines. 2024;12(12):2906. DOI: 10.3390/biomedicines12122906.
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Influence of Genetic Polymorphisms on the Age at Cancer Diagnosis in a Homogenous Lynch Syndrome Cohort of Individuals Carrying the MLH1:c.1528C>T South African Founder Variant
- Authors: Lutricia Ndou, Ramadhani Chambuso, Ursula Algar, Paul Goldberg, Adam Boutall, Raj Ramesar
- Year: 2024
- Citation: Ndou L, Chambuso R, Algar U, Goldberg P, Boutall A, Ramesar R. Influence of Genetic Polymorphisms on the Age at Cancer Diagnosis in a Homogenous Lynch Syndrome Cohort of Individuals Carrying the MLH1:c.1528C>T South African Founder Variant. Biomedicines. 2024;12(10):2201. DOI: 10.3390/biomedicines12102201.
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Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome
- Authors: Lutricia Ndou, Ramadhani Chambuso, Ziyaad Valley-Omar, George Rebello, Ursula Algar, Paul Goldberg, Adam Boutall, Raj Ramesar
- Year: 2024
- Citation: Ndou L, Chambuso R, Valley-Omar Z, Rebello G, Algar U, Goldberg P, Boutall A, Ramesar R. Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome. J Pers Med. 2024;14(6):575. DOI: 10.3390/jpm14060575.
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Investigating Somatic Variants and Pathways in Mismatch Repair-Deficient (dMMR) Colorectal Carcinoma in South Africa
- Authors: Aldera AP, van der Westhuizen J, Tsai W, Krause MJ, Yildiz S, Pillay K, Boutall A, Ramesar R
- Year: 2024
- Citation: Aldera AP, van der Westhuizen J, Tsai W, Krause MJ, Yildiz S, Pillay K, Boutall A, Ramesar R. Investigating Somatic Variants and Pathways in Mismatch Repair-Deficient (dMMR) Colorectal Carcinoma in South Africa. J Clin Pathol. 2024; DOI: 10.1136/jcp-2024-209526.
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Towards Uncovering the Role of Incomplete Penetrance in Maculopathies through Sequencing of 105 Disease-Associated Genes
- Authors: Hitti-Malin RJ, Panneman DM, Corradi Z, Boonen EGM, Astuti G, Dhaenens CM, Stöhr H, Weber BHF, Sharon D, Banin E, Raj Ramesar, et al.
- Year: 2024
- Citation: Hitti-Malin RJ, Panneman DM, Corradi Z, Boonen EGM, Astuti G, Dhaenens CM, Stöhr H, Weber BHF, Sharon D, Banin E, Ramesar R, et al. Towards Uncovering the Role of Incomplete Penetrance in Maculopathies through Sequencing of 105 Disease-Associated Genes. Biomolecules. 2024;14(3):367. DOI: 10.3390/biom14030367.
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Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome
- Authors: Lutricia Ndou, Ramadhani Chambuso, Ziyaad Valley-Omar, George Rebello, Ursula Algar, Paul Goldberg, Adam Boutall, Raj Ramesar
- Year: 2024
- Citation: Ndou L, Chambuso R, Valley-O