Kota Ramana | Immunology and Microbiology | Best Researcher Award

Dr. Kota Ramana | Immunology and Microbiology | Best Researcher Award

Professor at Noorda College of Osteopathic Medicine, United States

Dr. Kota V. Ramana is a Professor in the Department of Biomedical Sciences at Noorda College of Osteopathic Medicine, Provo, UT, USA. He specializes in cellular metabolism, oxidative stress, and inflammation, focusing on the role of aldo-keto reductases in inflammatory pathways. His research aims to understand how cellular metabolites regulate inflammatory responses in various diseases such as diabetes, sepsis, uveitis, asthma, and cancer. Dr. Ramana employs diverse genetic, biochemical, and cell biological techniques to explore the underlying mechanisms of inflammation and develop therapeutic strategies. He has made significant contributions to the understanding of oxidative stress signaling, cell death pathways, and polyol pathway enzymes in inflammatory conditions, with numerous publications in prestigious journals.

Professional Profile 

Education

Dr. Kota V. Ramana holds a Ph.D. in Biochemistry from the Postgraduate Institute of Medical Education and Research in India. His academic foundation laid the groundwork for his research into cellular metabolism and oxidative stress. This rigorous training has enabled him to delve into the biochemical pathways involved in inflammatory diseases, equipping him with a deep understanding of the complex biological systems at play. His educational background continues to shape his approach to studying inflammation and metabolic regulation in disease contexts, forming the basis for his current investigations and innovations in biomedical research.

Professional Experience

Dr. Kota V. Ramana currently serves as a Professor at Noorda College of Osteopathic Medicine, where he leads research on cellular metabolism and inflammation. Over the years, he has gained substantial experience in various aspects of biochemistry, including cell biology and genetic analysis. His work spans multiple inflammatory diseases, aiming to develop novel therapeutic approaches. Additionally, he has contributed to numerous journal articles on oxidative stress, cell signaling, and the role of enzymes in diseases. His academic and research roles have positioned him as a leader in his field, fostering collaborations and advancing scientific understanding of inflammation-related pathologies.

Research Interest

Dr. Kota V. Ramana’s research interests are primarily focused on understanding the molecular mechanisms that govern cellular metabolism, oxidative stress, and inflammation. His work aims to explore the role of aldo-keto reductases in the regulation of inflammatory pathways. He is particularly interested in how cellular metabolites influence signal transduction, cell death, and survival during inflammatory responses. His research addresses a wide range of inflammatory diseases, including diabetes, sepsis, uveitis, asthma, and cancer. By using genetic, biochemical, and cell biological techniques, Dr. Ramana seeks to develop therapeutic strategies that target oxidative stress and metabolic disturbances associated with these pathologies. His interdisciplinary approach to understanding cellular processes at the molecular level holds promise for advancing treatments for inflammatory and metabolic disorders.

Awards and Honors

Dr. Kota V. Ramana has earned recognition for his significant contributions to biomedical research, particularly in the areas of inflammation, oxidative stress, and cellular metabolism. Although specific awards and honors are not detailed, his academic achievements include numerous publications in prestigious peer-reviewed journals, such as the International Journal of Molecular Sciences, Current Molecular Medicine, and Future Medicinal Chemistry. These accolades highlight his excellence in research and his role as a thought leader in his field. His continued efforts to innovate therapeutic strategies for inflammation-related diseases demonstrate his commitment to advancing medical science and improving patient outcomes. Dr. Ramana’s reputation for high-quality research has led to collaborations with leading experts, further solidifying his position as a prominent figure in biochemistry and biomedical sciences.

Publications Top Noted

  1. Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe?
    • Authors: Jalali, A.M., Mitchell, K.J., Pompoco, C., Tran, S., Ramana, K.V.
    • Year: 2024
    • Citations: 0
  2. Anti-Inflammatory Potential of the Anti-Diabetic Drug Metformin in the Prevention of Inflammatory Complications and Infectious Diseases Including COVID-19: A Narrative Review
    • Authors: Plowman, T.J., Christensen, H., Aiges, M., Shah, M.H., Ramana, K.V.
    • Year: 2024
    • Citations: 5
  3. Significance of Vitamin Supplementation in Reducing the Severity of COVID-19
    • Authors: Aiges, M., Ramana, K.V.
    • Year: 2024
    • Citations: 0
  4. Role of Innate Immune and Inflammatory Responses in the Development of Secondary Diabetic Complications
    • Authors: Plowman, T.J., Shah, M.H., Fernandez, E., Aiges, M., Ramana, K.V.
    • Year: 2023
    • Citations: 7
  5. Therapeutic Potential of Vitamin B1 Derivative Benfotiamine from Diabetes to COVID-19
    • Authors: Allowitz, K.V., Yoo, J.J., Taylor, J.R., Harames, K., Ramana, K.V.
    • Year: 2022
    • Citations: 2
  6. Aldose Reductase Regulates Doxorubicin-Induced Immune and Inflammatory Responses by Activating Mitochondrial Biogenesis
    • Authors: Sonowal, H., Saxena, A., Qiu, S., Srivastava, S., Ramana, K.V.
    • Year: 2021
    • Citations: 13
  7. Development of Aldose Reductase Inhibitors for the Treatment of Inflammatory Disorders and Cancer: Current Drug Design Strategies and Future Directions
    • Authors: Sonowal, H., Ramana, K.V.
    • Year: 2021
    • Citations: 17
  8. 2′-Hydroxyflavanone Prevents LPS-Induced Inflammatory Response and Cytotoxicity in Murine Macrophages
    • Authors: Sonowal, H., Ramana, K.V.
    • Year: 2020
    • Citations: 8
  9. Didymin by Suppressing NF-κB Activation Prevents VEGF-Induced Angiogenesis in Vitro and In Vivo
    • Authors: Shukla, K., Sonowal, H., Saxena, A., Ramana, K.V.
    • Year: 2019
    • Citations: 20
  10. Erratum: Expression of Concern: Aldose Reductase Mediates the Lipopolysaccharide-Induced Release of Inflammatory Mediators in RAW264.7 Murine Macrophages
  • Authors: Ramana, K.V., Fadl, A.A., Tammali, R., Chopra, A.K., Srivastava, S.K.
  • Year: 2019
  • Citations: 0

Hua Jin | Immunology and Microbiology | Best Researcher Award

Ms. Hua Jin | Immunology and Microbiology | Best Researcher Award

Research Assistant at Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, China

Ms. Hua Jin is a highly accomplished researcher in hepatology and immunology. She holds an M.B. in clinical medicine and advanced degrees (M.S. and M.D.) in hepatology from Capital Medical University and Beijing Friendship Hospital, China. Currently, she works as a researcher at the Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital. Her research focuses on liver injury and immune responses, particularly the role of OX40 in hepatic ischemia-reperfusion injury and drug-induced liver damage. She has co-authored numerous high-impact publications in journals like JCI Insight, British Journal of Pharmacology, and Cell Reports. Her groundbreaking work has earned her recognition, including the prestigious American Transplant Congress Young Investigator Award in 2021. In addition to her research, she has presented her findings at major international conferences, including the Asian Pacific Association for the Study of the Liver and the American Transplant Congress.

Professional Profile

Education

Ms. Hua Jin has a strong academic background in clinical medicine and hepatology. She completed her undergraduate studies in Clinical Medicine at Chongqing Medical University in China, earning her M.B. degree from 2009 to 2014. Following this, she pursued advanced training in hepatology, earning her M.S. degree from the Experimental and Translational Research Center at Beijing Friendship Hospital, Capital Medical University, from 2015 to 2018. Building on this foundation, she furthered her expertise by obtaining an M.D. in hepatology, also from the Experimental and Translational Research Center, between 2018 and 2021. This rigorous education provided Ms. Jin with a deep understanding of both clinical and research aspects of hepatology, setting the stage for her current work in immunology and liver disease. Her academic achievements reflect a commitment to advancing knowledge in medical research, particularly in the areas of liver injury and immune system regulation.

Professional Experience

Ms. Hua Jin has extensive professional experience in the field of medical research, particularly in hepatology and immunology. After completing her advanced degrees, she began her research career as a Research Assistant at the Immunology Research Center for Oral and Systemic Health at Beijing Friendship Hospital, Capital Medical University, from 2021 to 2024. During this time, she worked on critical research related to immune responses in liver injury, with a focus on the role of OX40 in liver diseases. In 2024, she transitioned to her current role at the Medical Research Center, Beijing Institute of Respiratory Medicine, and Beijing Chao-Yang Hospital, where she continues her work in hepatology and immunology. Throughout her career, Ms. Jin has contributed to numerous high-impact research projects, authored multiple publications in prestigious journals, and presented her work at leading international conferences, establishing herself as a promising young investigator in the field of liver disease and immune system regulation.

Research interest

Ms. Hua Jin’s research interests primarily focus on hepatology, immunology, and liver diseases. Her work investigates the immune mechanisms underlying liver injury, particularly the role of immune checkpoints like OX40 in hepatic ischemia-reperfusion injury, drug-induced liver injury, and non-alcoholic steatohepatitis (NASH). She is particularly interested in how immune responses, both innate and adaptive, contribute to liver diseases, aiming to identify potential therapeutic targets for improving liver function and preventing damage. Her research also delves into the cellular and molecular dynamics of immune cells such as neutrophils and T cells in liver injury. Through the application of advanced techniques like single-cell transcriptomics, she explores the heterogeneity of immune cell populations and their roles in inflammation and liver repair. Ms. Jin’s work seeks to bridge the gap between basic immunology and clinical hepatology, with the goal of developing novel, immune-based therapeutic strategies for liver diseases.

Award and Honor

Ms. Hua Jin has received notable recognition for her research contributions, highlighting her prominence in the fields of hepatology and immunology. In 2021, she was honored with the prestigious American Transplant Congress Young Investigator Award, which acknowledges exceptional young researchers making significant strides in transplant medicine and immunology. This award reflects the high regard her work has garnered within the scientific community. Additionally, Ms. Jin has published multiple influential papers in top-tier journals, such as JCI Insight, Cell Reports, and British Journal of Pharmacology, further cementing her status as a rising star in medical research. Her innovative studies on immune responses in liver injury and the role of immune checkpoints like OX40 have gained widespread recognition. Furthermore, she has presented her research at prominent international conferences, including the Asian Pacific Association for the Study of the Liver and American Transplant Congress, showcasing her contributions to the global medical research community.

Conclusion

Hua Jin demonstrates the core qualities of an outstanding researcher: academic excellence, groundbreaking contributions, and recognition within his field. His work on immune responses in liver injury is cutting-edge and contributes valuable insights to the medical community. With continued growth in his research portfolio and a potential increase in his mentorship and international networking, he could further enhance his impact. Based on these strengths, Hua Jin is highly deserving of consideration for the Best Researcher Award.

Publications Top Noted

  • “Rebalancing liver-infiltrating CCR3+ and CD206+ monocytes improves diet-induced NAFLD”
    • Authors: Sun, G., Wang, Y., Yang, L., Zhang, Z., Zhang, D.
    • Year: 2023
    • Citations: 5
  • Erratum to “Isolation and purification of immune cells from the liver”
    • Authors: Shi, W., Wang, Y., Zhang, C., Zhang, D., Sun, G.
    • Year: 2023
    • Citations: 0
  • “OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis”
    • Authors: Xu, L., Tian, D., Zhou, M., Zhang, D., Wu, J.
    • Year: 2022
    • Citations: 2
  • “Reciprocal alterations in circulating and hepatic gamma–delta T cells in patients with primary biliary cholangitis”
    • Authors: Chen, S., Lv, T., Sun, G., Zhang, D., Jia, J.
    • Year: 2022
    • Citations: 6
  • “The Critical and Diverse Roles of CD4–CD8– Double Negative T Cells in Nonalcoholic Fatty Liver Disease”
    • Authors: Li, C., Du, X., Shen, Z., Zhang, D., Sun, G.
    • Year: 2022
    • Citations: 11
  • “CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis”
    • Authors: Sun, G., Zhao, X., Li, M., Zhang, Z., Zhang, D.
    • Year: 2021
    • Citations: 22
  • “Transcriptome landscape of double negative T cells by single-cell RNA sequencing”
    • Authors: Yang, L., Zhu, Y., Tian, D., Zhao, Y., Zhang, D.
    • Year: 2021
    • Citations: 26
  • “Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress”
    • Authors: Li, S., Jin, H., Sun, G., Zhang, D., Wang, S.
    • Year: 2021
    • Citations: 14
  • “Isolation and purification of immune cells from the liver”
    • Authors: Shi, W., Wang, Y., Zhang, C., Zhang, D., Sun, G.
    • Year: 2020
    • Citations: 34
  • “Critical role of OX40 in drug-induced acute liver injury”
    • Authors: Zhang, C., Jin, H., Wang, Y., Sun, G., Zhang, D.
    • Year: 2020
    • Citations: 4