Education:
Yuwen completed a Bachelor of Science in Biological Sciences at Peking University in 2008, followed by a Ph.D. in Chemistry at Purdue University from 2008 to 2014. During this time, under the guidance of Prof. Nikolai Skrynnikov, Yuwen’s research delved into new experimental and theoretical tools for studying protein systems with elements of structural disorder.
Research Focus:
Yuwen’s research primarily focuses on the development and application of advanced NMR methodologies to investigate the structure and dynamics of proteins, particularly those with intrinsic disorder. This includes studying conformational exchanges, molecular interactions, and dynamics in various biological systems.
Professional Journey:
After completing a Ph.D., Yuwen pursued postdoctoral research at Purdue University and the University of Toronto, working under the mentorship of Prof. Nikolai Skrynnikov and Prof. Lewis E. Kay, respectively. During these postdoctoral positions, Yuwen contributed to pioneering research in the field of NMR spectroscopy, particularly in the development of new methodologies for studying large biomolecular systems.
Honors & Awards:
Yuwen’s contributions to the field have been recognized with prestigious honors and awards, including the Canadian Institutes of Health Research (CIHR) Fellowship. These accolades underscore Yuwen’s significant impact and leadership in the field of analytical chemistry and biochemistry.
Publications Top Noted & Contributions:
Yuwen has authored numerous publications in peer-reviewed journals, showcasing groundbreaking research in the field of NMR spectroscopy and protein dynamics. Yuwen’s contributions include studies on protein conformational exchanges, molecular interactions, and the development of innovative NMR techniques.
Optimization of TROSY-and anti-TROSY-based 15N CPMG relaxation dispersion experiments through phase cycling
- Authors: Y. Cui, Y. Jin, Y. Hou, X. Han, H. Cao, L.E. Kay, T. Yuwen
- Published in the Journal of Magnetic Resonance in 2024
- Discusses optimization techniques for relaxation dispersion experiments using TROSY and anti-TROSY methods, crucial in studying protein dynamics by NMR spectroscopy.
Protein Conformational Exchanges Modulated by the Environment of Outer Membrane Vesicles
- Authors: G. Wang, G. Yu, D. Gao, G. Jiang, H. Wang, T. Yuwen, X. Zhang, C. Li, D. Yang, …
- Published in The Journal of Physical Chemistry Letters in 2023
- Investigates how the environment of outer membrane vesicles affects protein conformational dynamics.
Protein conformational exchanges modulated by the environment of outer membrane vesicles
- Authors: L. He, M. Liu, G. Wang, G. Yu, D. Gao, G. Jiang, H. Wang, T. Yuwen, X.Z. Zhang, …
- Published in 2022
- Possibly a related study to the one published in The Journal of Physical Chemistry Letters, exploring similar themes of protein dynamics influenced by vesicle environments.
Dynamics in protein crystals: insights from MD simulations complement new solid-state NMR and X-ray data
- Authors: O.N. Rogacheva, S.A. Izmailov, V. Kurauskas, A. Shilova, P. Ma, Y. Xue, …
- Published in FEBS JOURNAL in 2016
- Discusses insights gained from molecular dynamics simulations complementing experimental data from solid-state NMR and X-ray crystallography, focusing on dynamics within protein crystals.
Loss of Protein Stability due to Formation of Intermolecular Disulfide Bonds under the Effect of Oxidative Stress: Case Study of the RRM2 Domain from Neuropathological Protein …
- Authors: S.O. Rabdano, I.S. Podkorytov, S.A. Izmailov, Y.V. Pivovarova, A.P. Yakimov, …
- Published in Biophysical Journal in 2016
- Investigates the loss of protein stability due to the formation of intermolecular disulfide bonds under oxidative stress conditions, focusing on the RRM2 domain.
Research Timeline:
Yuwen’s research journey spans from undergraduate studies at Peking University to postdoctoral research positions at Purdue University and the University of Toronto, culminating in a faculty position at Peking University. Throughout this timeline, Yuwen has consistently demonstrated a commitment to advancing knowledge in analytical chemistry and biochemistry through innovative research endeavors.
